A Forum for Advancing Discussion of Hair Loss Treatments and Science
This is perhaps the most exciting new hair loss treatment in development. Currently in Phase 3 clinical trials, pyrilutamide (KX-826) is very close to becoming the first FDA-approved treatment for androgenetic alopecia in decades.
Continue reading Kintor Pyrilutamide (KX-826): The Most Promising Hair Loss Cure in the Pipeline?
HMI-115 is a human monoclonal antibody drug being developed by Chinese company Hope Medicine for the treatment of androgenetic alopecia (male and female pattern hair loss).
In November 2021, Hope Medicine received FDA approval to start Phase 2 clinical trials of HMI-115 for androgenetic alopecia. In 2020, the FDA also approved Phase 2 trials of the same drug for endometriosis. Phase 2 clinical trials of HMI-115 for hair loss are due to begin in the USA soon.
In Australia, Phase 1 trials are currently underway. The trial is due to last 6 months, with 20 participants receiving injections every 2 weeks (12 injections total).
Since November, one of the participants in this Phase 1 Australian trial – a 37 year old man with the Reddit username moeman32 – has been posting some details of his experience to Reddit.
Continue reading Hope Medicine Prolactin Receptor Monoclonal Antibody (HMI-115) for Hair Loss
Antihistamines are commonly used to alleviate the symptoms of allergies. If you’ve ever suffered from hay fever, you’ll know these drugs can be effective at reducing itchiness and sneezing. But antihistamines may also reduce PGD2 levels and inflammation – both of which are linked to hair loss. This has led some hair loss sufferers to try out antihistamines in an attempt to beat baldness. One antihistamine – cetirizine – is particularly popular online for this purpose. But does it really work for hair loss?
Continue reading Cetirizine for Hair Loss: Are Antihistamines a Cure for Baldness?
Dihydrotestosterone (DHT): it’s been blamed as the cause of hair loss ever since Dr. James Hamilton’s pioneering research in the 1940s. Yet despite Hamilton himself casting doubt on this theory, mainstream medicine has left this hypothesis mostly unchallenged. And while there is good evidence to support the link between DHT and hair loss, there are a number of problems with this explanation. So is DHT really the cause of hair loss? Or is it time for a new theory? Continue reading DHT and Hair Loss: Is It Really The Main Cause?
Have you ever noticed how bald men’s scalps often look shiny? How the skin appears harder and more tight compared to skin elsewhere on the body? It’s not a coincidence. In fact, these characteristics provide valuable insights into the causes of pattern hair loss. Most importantly, though, they could provide the key to reversing androgenetic alopecia and regrowing a full head of hair.
Continue reading The Link Between Pattern Hair Loss and Fibrosis (Collagen)
Like many medical discoveries, this one was made by accident. JAK inhibitors – a class of drugs used to treat conditions such as bone marrow cancer and rheumatoid arthritis – have been hailed as a miracle cure for hair loss. However, the truth is a little more complicated than headlines would suggest. Nevertheless, these drugs have great potential to help understand and even cure many forms of hair loss.
Continue reading Updated: Latest on JAK Inhibitors for Hair Loss
If you haven’t heard about it yet, CB0301 (brand name Breezula) is a topical anti-androgen that is being trialled for hair loss. It’s just finished phase 2 dose-ranging testing and shows promise. So does it work? When will it be available? Let’s take a look at this exciting future hair loss treatment.
Continue reading Updated: CB0301 (Breezula/ Clascoterone) Phase 2 Results
Propecia, the 1mg finasteride pill approved by the FDA to treat hair loss, may be far stronger than necessary. Numerous studies have shown doses as low as 0.2mg reduce DHT by the same amount as the prescribed 1mg tablet. So is such a high dose necessary to prevent hair loss? Is there a lower risk of side effects when taking a lower dose? In this article we’ll take a look at what the optimal finasteride dose for hair loss prevention is.
Continue reading What is the Best Finasteride Dose for Hair Loss? 1mg? 0.5mg? 0.25mg?
As if going bald wasn’t bad enough! Research suggests pattern hair loss is more than just a cosmetic issue. Numerous studies have identified links between androgenetic alopecia and a range of diseases. Perhaps most worryingly, bald men are statistically more likely to suffer from heart disease. The good news is that identifying the common cause could prevent heart problems – and even stop hair loss.
Continue reading Pattern Hair Loss and Heart Disease: A Common Cause?
It’s popularly touted as a natural hair loss treatment – but does it actually work? Rich in polyphenols, vitamins and minerals, olive oil is often recommended as both a topical therapy and a dietary addition to prevent hair loss. So what does the evidence say? Is olive oil good for hair loss?
Continue reading Is Olive Oil Good For Hair Loss? (Oleuropein)
